1.   A major problem arose from the way in which the adjustable peg system was operated.

2.   A major problem in valuing the volunteer Market in sport is that no accepted shadow wage rate is used.

3.   A major problem is how to make the comparison groups as similar to the experimental group as possible.

4.   A major problem with the approach adopted is that there is not enough detail to allow you to actually perform the analysis.

5.   A second major problem is the loss of bitterness due to precipitation in boiling and in fermentation.

6.   A shortage of trained nurses is posing major problems.

7.   Alternative Energy Sources One of the major problems of fossil fuels and particularly coal is pollution.

8.   And this particular design feature led to a major problem that no one had really anticipated.

9.   Another major problem can arise in house price differentials.

10.   As a way of tackling the major problem of making something essentially static into something always forward-moving, I offer this tip.